Oscar De la Hoya has fought better opposition, is bigger and maybe stronger. He is an orthodox fighter who looks to land fight-ending left hooks following stiff jabs, but the edge goes to Floyd Mayweather Jr. who is the complete package blessed with superior speed, stamina, sharp punching, a solid chin and great defense. He has subtle old school moves and his great counter punching ability should give him the advantage in any heated exchanges, but he needs to be weary of THAT hook.
Late-developing issues between Floyd Sr and Roger seem unsettling, but Mayweather has great pedigree and focus. De la Hoya has been taken out once and down several times. He has lost two of his last four fights, looked bad against Sturm, and beat a made-to-order opponent in Mayorga. Still, he has been in many mega fights and also has great focus.
In my view, the fight will be overly tactical, unless De la Hoya can use his size to back up Mayweather in which case it could spell big trouble.